Controlling Crystallization Scale-up in the Chemical Industry – Ensuring Success from Lab to Manufacturing

Controlling Crystallization Scale-up in the Chemical Industry – Ensuring Success from Lab to Manufacturing
Wed Mar 24 2010 08:00 GMT [English]
Wed Mar 24 2010 13:00 GMT [English]
Wed Mar 24 2010 18:00 GMT [English]
Register for the Controlling Crystallization Scale-up in the Chemical Industry Webinar

Crystallization is one of the most common separation and purification techniques in the fine chemical and bio-pharmaceutical industries. Once considered an art, crystallization has developed into a sophisticated science rooted in understanding and control of particle nucleation, growth, agglomeration, and breakage. A crystallization process must take into account the complex interaction of particles with control parameters and process equipment. Often the crux of crystallization process development is the scale-up from the lab to manufacturing plant. Problems such as batch to batch inconsistencies in the crystals size distribution and the crystal purity profile can have a significant impact on product quality and downstream process unit operations including filtration, drying, milling, and product formulation.
 
With the advent of Process Analytical Technology (PAT) such as FBRM®, PVM®, FTIR, and Raman scientists can quickly measure solution and particle phase behavior in situ without pulling samples. This webinar reviews the simple application of in situ process analytical tools to avoid problems by understanding, optimizing, and controlling a crystallization process throughout scale-up.
 
Interactive
At the end of this online seminar there will be an interactive Q&A session providing you with the opportunity to ask questions relevant to your particular application.

LinkedIn Crystallization Community
Follow us on Twitter
Related topics: crystallization scale-up, crystallisation scale-up, particle nucleation, particle growth, particle agglomeration, particle breakage, process development, crystal size distribution, batch to batch inconsistency, crystal purity profile, filtration, drying, milling, product formulation, Process Analytical Technology , PAT, pharmaceutical industry, fine chemical industry, FBRM, PVM, FTIR, Raman, in situ FTIR Analytics, in situ reaction spectroscopy, solution phase, particle phase, in situ process analytical tools, Lasentec